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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2918 | Cholesteryl Acetate | Cholesterin acetate,Cholesterol acetate,Acebrochol | Others |
Cholesteryl Acetate is a cholesterol ester obtained from the esterification of the hydroxyl group of cholesterol with acetic acid. It functions as a metabolite in the human body and is both a cholesterol ester and an ace... | |||
T1664 | Meglutol | Dicrotalic acid,3-Hydroxy-3-methylglutaric acid | Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve... | |||
TN1655 | Ganoderal A | Others | |
The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of choles... | |||
T15709 | Lapaquistat acetate | TAK-475 | Others |
Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowerin... | |||
T71559 | Melanotan II acetate | ||
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases... | |||
T36998 | 7β,27-dihydroxy Cholesterol | 7β,27-DHC,7β,27-dihydroxy Cholesterol | |
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res... | |||
T70856 | 3-Oxobetulin Acetate | ||
3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H46... | |||
T62598 | Pitavastatin sodium | ||
Pitavastatin (NK-104) sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and a potent inducer of the hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor. pitavastatin sodium inhibit... | |||
T69244 | Betulonaldehyde | ||
Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H1... | |||
T36130 | 22(S)-hydroxy Cholesterol | 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol | |
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc... | |||
T35927 | C2 L-threo Ceramide (d18:1/2:0) | C2 L-threo Ceramide (d18:1/2:0) | |
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o... | |||
T37291 | Lyso-Globotriaosylceramide (d18:1) | Lyso-Globotriaosylceramide (d18:1) | |
Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also ... |